L-Aspartic Acid → L-Aspartic acid, sodium salt (1:2)

HRID 2302019Notes

Reaction equation

HRID 2302019 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5].[OH-].[Na+:11]>O>[NH2:1][C@H:2]([C:7]([O-:9])=[O:8])[CH2:3][C:4]([O-:6])=[O:5].[Na+:11].[Na+:11]

Participants

4

Reactant 2

HCID 5960L-Aspartic AcidHCID 14798Sodium Hydroxide

Product 1

HCID 21806L-Aspartic acid, sodium salt (1:2)

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 10 g of aspartic acid (0.0751 mole) in 28 ml of water plus 26.6 g of monoamino polyoxyalkylene (Jeffamine M-2070, 0.47 meq NH2/g, 0.0125 mole NH2) was mixed with 4.7 g of 50% NaOH. The salt of sodium aspartate and polyoxyalkylene amine was formed by lyophilization, and a sample of 0.05 g of 4-methoxyphenol was added as an antioxidant. This mixture was heated in a flask in an oil bath at 180° C. for 20.5 hours. Subsamples were taken at 2, 4, 7, and 13.5 hours.

Sources & evidence

ORD record
ord-49a51947bb554f269e44b96a57beed52
Source dataset
uspto-grants-2002_08
Patent number
US06429266B2

Reaction notes

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