Pyridine → N-(Tricyclo[4.3.1.1(3,8)]undec-3-yl)-2-quinoxalinecarboxamide

HRID 2302038Notes

Reaction equation

HRID 2302038 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[C:11](Cl)=[O:12].Cl.[CH:15]12[CH2:25][CH:20]3[CH2:21][CH:22]([CH2:24][C:17]([NH2:26])([CH2:18][CH2:19]3)[CH2:16]1)[CH2:23]2.N1C=CC=CC=1>O>[CH:15]12[CH2:25][CH:20]3[CH2:21][CH:22]([CH2:24][C:17]([NH:26][C:11]([C:2]4[CH:3]=[N:4][C:5]5[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=5)[N:1]=4)=[O:12])([CH2:18][CH2:19]3)[CH2:16]1)[CH2:23]2

Participants

5

Reactant 3

HCID 1049PyridineHCID 2734681Quinoxaline-2-carbonyl chlorideHCID 22136454Tricyclo[4.3.1.1~3,8~]undec-3-ylamine hydrochloride

Product 1

HCID 22136388N-(Tricyclo[4.3.1.1(3,8)]undec-3-yl)-2-quinoxalinecarboxamideYield 57%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared from 2-quinoxaloyl chloride (135 mg, 0.70 mmol), tricyclo[4.3.1.1(3,8)]undec-3-ylamine hydrochloride (100 mg, 0.60 mmol), pyridine (5 mL), and water (50 mL) yielding 110 mg (57%) of (168):

Sources & evidence

ORD record
ord-c5ae2518cd2549b8ae4c7d7ed3f99f48
Source dataset
uspto-grants-2002_08
Patent number
US06429207B1

Reaction notes

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