反应详情

温度

0 °C

2-Quinoxaloyl chloride (207 mg, 1.07 mmol) in dichloromethane (1 mL) was added to a solution of phentermine (160 mg, 1.07 mmol) in dichloromethane (3 mL) cooled to 0° C.The reaction was allowed to warm to 25° C.After 5 min, the reaction mixture was diluted with ethyl acetate (40 mL) and washed with 1 M sodium hydroxide (2×40 mL). The organic layer was dried (anhydrous magnesium sulfate), filtered through silica gel, and rotary evaporated. This provided 51 mg (16%) of (108):

1. temperatureto warm to 25° C
2. washwashed with 1 M sodium hydroxide (2×40 mL)
3. dry with materialThe organic layer was dried (anhydrous magnesium sulfate)
4. filtrationfiltered through silica gel, and rotary evaporated