Thionyl Chloride → HCID 178461307, compound

HRID 2302065Notes

Reaction equation

HRID 2302065 reaction equation
S(Cl)([Cl:3])=O.[CH3:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([NH:12]C(C2C=NC3C(C=2Cl)=CC2OCCOC=2C=3)=O)[CH2:8][CH2:7]1>C(N(CC)CC)C>[ClH:3].[CH3:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([NH2:12])[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178461351HCID 178461351, compound

Product 1

HCID 178461307HCID 178461307, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The crude acid (500 mg), thionyl chloride, trans-4-methylcyclohexylamine hydrochloride (150 mg, 1 mmol), and triethylamine (0.3 mLs) afforded crude N-(trans-4-methylcyclohexyl)-4-chloro-6,7-ethylenedioxyquinoline-3-carboxamide.

Sources & evidence

ORD record
ord-de2500169479429e836763585b16c4aa
Source dataset
uspto-grants-2002_08
Patent number
US06429207B1

Reaction notes

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