反应详情

A solution of 114 (1.9 g) in DMF (100 mL) was treated with SnCl2-2H2O (4 g). After 4 h, additional SnCl22H2O (1 g) was added three times over three days. The solvent was then evaporated, the residue suspended in H2O-EtOAc, the mixture neutralized with 5N NaOH, and the mixture filtered. The. organics were separated, washed with brine, dried, and the solvent evaporated to give a brown foam (1.9 g).

1. additionadditional SnCl22H2O (1 g) was added three times over three days
2. customThe solvent was then evaporated
3. filtrationthe mixture filtered
4. customorganics were separated
5. washwashed with brine
6. customdried
7. customthe solvent evaporated