Sodium hydride → HCID 9946980, compound

HRID 230212Notes

Reaction equation

HRID 230212 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:8]=[C:9]3[NH:17][CH2:16][CH2:15][CH2:14][N:10]3[C:11](=[O:13])[CH:12]=2)=[CH:3][CH:2]=1.[H-].[Na+].[C:20]1([CH2:26][CH2:27][C:28](Cl)=[O:29])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(Cl)(Cl)Cl>[C:20]1([CH2:26][CH2:27][C:28]([N:17]2[C:9]3=[N:8][C:7]([C:4]4[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=4)=[CH:12][C:11](=[O:13])[N:10]3[CH2:14][CH2:15][CH2:16]2)=[O:29])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 64801Benzenepropanoyl chlorideHCID 135830901HCID 135830901, compound

Product 1

HCID 9946980HCID 9946980, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A suspension of 0.2 g (0.87 mmol) of 2-pyridin-4-yl-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one in 5 ml of chloroform was treated with 26 mg (1.14 mmol) of sodium hydride (60% suspension in mineral oil) and the resulting mixture was stirred at room temperature for 15 min and then cooled to 0° C. 0.148 g (0.964 mmol) of 3-phenylpropionyl chloride was added and the reaction mixture was stirred at room temperature during 18 h.

Workup

  1. temperaturecooled to 0° C
  2. stirringthe reaction mixture was stirred at room temperature during 18 h.

Sources & evidence

ORD record
ord-e296e2cf742241fbb194e3de9ac7d048
Source dataset
uspto-grants-2009_07
Patent number
US07566720B2

Reaction notes

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