Triethylamine → HCID 53901687, compound

HRID 2302219Notes

Reaction equation

HRID 2302219 reaction equation
[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](Cl)=[O:7])#[N:2].[CH3:15][N:16]([CH3:24])[CH:17]=[CH:18][C:19]([O:21][CH2:22][CH3:23])=[O:20].C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([C:18](=[CH:17][N:16]([CH3:24])[CH3:15])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[O:7])#[N:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 121015Ethyl 3-(N,N-dimethylamino)acrylateHCID 186187613-Cyano-2,4,5-trifluoro-benzoyl chloride

Product 1

HCID 53901687HCID 53901687, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of 55 g of 3-cyano-2,4,5-trifluoro-benzoylchloride in 50 ml of toluene is added dropwise to a solution of 36.5 g of ethyl 3-dimethylamino-acrylate and 26.5 g of triethylamine in 140 ml of toluene such that the temperature remains between 50 and 55° C. Stirring is then carried out at 50° C. for a further 2 hours. The reaction mixture is concentrated in vacuo and employed in the next stage without further working up.

Workup

  1. customremains between 50 and 55° C
  2. concentrationThe reaction mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-70c7bb6dc0714c64ae94d363ef1d6da4
Source dataset
uspto-grants-2002_08
Patent number
US06432948B1

Reaction notes

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