反应详情

A solution of 55 g of 3-cyano-2,4,5-trifluoro-benzoylchloride in 50 ml of toluene is added dropwise to a solution of 36.5 g of ethyl 3-dimethylamino-acrylate and 26.5 g of triethylamine in 140 ml of toluene such that the temperature remains between 50 and 55° C. Stirring is then carried out at 50° C. for a further 2 hours. The reaction mixture is concentrated in vacuo and employed in the next stage without further working up.

1. customremains between 50 and 55° C
2. concentrationThe reaction mixture is concentrated in vacuo