3-Cyanopyridine → HCID 18460129, compound

HRID 2302669Notes

Reaction equation

HRID 2302669 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[NH2:9][C:10]1[S:11][C:12]([CH3:21])=[C:13]([Cl:20])[C:14]=1[C:15](OCC)=O.O=P(Cl)(Cl)[Cl:24]>>[Cl:24][C:15]1[C:14]2[C:13]([Cl:20])=[C:12]([CH3:21])[S:11][C:10]=2[N:9]=[C:1]([C:3]2[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=2)[N:2]=1

Participants

4

Reactant 3

HCID 793-CyanopyridineHCID 24813Phosphorus oxychlorideHCID 18459926HCID 18459926, compound

Product 1

HCID 18460129HCID 18460129, compound

Procedure

With the procedure of Example 477, the reaction of 3-cyanopyridine and 2-amino-4-chloro-5-methyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyridin-3-yl)-5-chloro-6-methyl-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record
ord-12b02c826ba54d53aa4730bde91d7f7c
Source dataset
uspto-grants-2002_08
Patent number
US06432950B1

Reaction notes

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