1-Bromopropane → HCID 57762619, compound

HRID 230322Notes

Reaction equation

[I:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:4][CH:3]=1.[CH2:15](Br)[CH2:16][CH3:17].[H-].[Na+]>>[I:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:15][CH2:16][CH3:17])[C:9]2[N:10]=[CH:11][CH:12]=[CH:13][N:14]=2)=[CH:6][CH:7]=1

Participants

Reactant 3

HCID 78401-Bromopropane

HCID 24758Sodium hydride

HCID 57762548N-(4-iodophenyl)pyrimidin-2-amine

Product 1

HCID 57762619HCID 57762619, compound

Procedure

In the same manner as in Reference Example 13, N-(4-iodophenyl)pyrimidin-2-amine (300 mg) and propyl bromide (0.11 ml) were reacted in the presence of sodium hydride to obtain N-(4-iodophenyl)-N-propylpyrimidin-2-amine (348 mg).

Sources & evidence

ORD record: ord-c381db962f7f4e08a027b4db1e649909
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07566724B2

Reaction notes

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