5-Bromoindole → 5-Bromo-1-methyl-1H-indole

HRID 2303287Notes

Reaction equation

HRID 2303287 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.Br[C:12]1C=CC=C2C=1N(C)C=C2.BrC1C=CC=C2C=1NC=C2>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:12])[CH:6]=[CH:5]2

Participants

4

Reactant 3

HCID 249055-BromoindoleHCID 27570207-BromoindoleHCID 219500697-Bromo-1-methyl-1H-indole

Product 1

HCID 2857575-Bromo-1-methyl-1H-indole

Procedure

5-Bromo-1-methylindole was prepared from 5-bromoindole as described for the preparation of 7-bromo-1-methylindole from 7-bromoindole. Purification by chromatography using EtOAc:petroleum ether 1:10

Workup

  1. customPurification by chromatography

Sources & evidence

ORD record
ord-11e7f7713be74a2c9c1624301c833944
Source dataset
uspto-grants-2002_08
Patent number
US06432962B1

Reaction notes

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