Hydrazine hydrate (1:1) → HCID 18618216, compound

HRID 2303291Notes

Reaction equation

HRID 2303291 reaction equation
[NH2:1][C:2]1[C:6]([CH3:7])=[CH:5][S:4][C:3]=1[C:8]([O:10]C)=O.O.[NH2:13][NH2:14]>C(O)CCC>[NH2:1][C:2]1[C:6]([CH3:7])=[CH:5][S:4][C:3]=1[C:8]([NH:13][NH2:14])=[O:10]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 123584Methyl 3-amino-4-methylthiophene-2-carboxylate

Product 1

HCID 18618216HCID 18618216, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A solution of methyl 3-amino-4-methyl-2-thenoate (25 g) and hydrazine hydrate (20 ml) in butanol (150 ml) was heated under reflux for 18 hours. On cooling the solvent was removed and the residue was recrystallised from toluene to give the title product, m.p. 141-143° C.

Workup

  1. temperatureunder reflux for 18 hours
  2. temperatureOn cooling the solvent
  3. customwas removed
  4. customthe residue was recrystallised from toluene

Sources & evidence

ORD record
ord-d57aef1df9174abb907c820a1e63d0ec
Source dataset
uspto-grants-2002_08
Patent number
US06432964B1

Reaction notes

Loading…