Formic Acid → Methyl 4-formamidothiophene-3-carboxylate

HRID 2303294Notes

Reaction equation

HRID 2303294 reaction equation
[NH2:1][C:2]1[C:3]([C:7]([O:9][CH3:10])=[O:8])=[CH:4][S:5][CH:6]=1.O.O.O.[C:14]([O-])(=[O:16])C.[Na+].C(O)=O>O>[CH:14]([NH:1][C:2]1[C:3]([C:7]([O:9][CH3:10])=[O:8])=[CH:4][S:5][CH:6]=1)=[O:16]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 2777610Methyl 4-aminothiophene-3-carboxylateHCID 23665404Sodium Acetate Trihydrate

Product 1

HCID 2777637Methyl 4-formamidothiophene-3-carboxylate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A stirred solution of methyl 4-amino-3-thenoate (4 g), sodium acetate trihydrate (2.8 g) and formic acid (27 ml) was heated at 95° C. for 1 hour. On cooling the solution was poured into water, and the solution filtered to give the title product as a solid.

Workup

  1. temperatureOn cooling the solution
  2. filtrationthe solution filtered

Sources & evidence

ORD record
ord-b19aee2082594237b630c37977f4c646
Source dataset
uspto-grants-2002_08
Patent number
US06432964B1

Reaction notes

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