Hydrochloric Acid → HCID 178462327, compound

Participants

Reaction Steps

adding anhydrous hydrogen chloride in an polar solvent such as isopropanol to a solution of 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-phenyl)ethoxy)-4-(5-(dimethylamino)methyl-1,2,3-triazol-4-yl)methyl-3-(S)-(4-fluorophenyl)-morpholine in second polar solvent such as ethyl acetate, followed by addition of an antisolvent such as heptane to give Form I of 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)4-(5-(dimethylamino)methyl-1,2,3-triazol-4-yl)methyl-3-(S)-(4-fluorophenyl)morpholine hydrochloride.

Provenance & Evidence