Hydrochloric Acid → HCID 178462327, compound

HRID 2303315Notes

Reaction equation

HRID 2303315 reaction equation
[ClH:1].C(O)(C)C.[F:6][C:7]([F:45])([F:44])[C:8]1[CH:9]=[C:10]([C@H:18]([O:20][C@H:21]2[O:26][CH2:25][CH2:24][N:23]([CH2:27][C:28]3[N:29]=[N:30][NH:31][C:32]=3[CH2:33][N:34]([CH3:36])[CH3:35])[C@H:22]2[C:37]2[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=2)[CH3:19])[CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=1.C(OCC)(=O)C>CCCCCCC>[ClH:1].[F:45][C:7]([F:6])([F:44])[C:8]1[CH:9]=[C:10]([C@H:18]([O:20][C@H:21]2[O:26][CH2:25][CH2:24][N:23]([CH2:27][C:28]3[N:29]=[N:30][NH:31][C:32]=3[CH2:33][N:34]([CH3:35])[CH3:36])[C@H:22]2[C:37]2[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=2)[CH3:19])[CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 8857Ethyl AcetateHCID 178462326HCID 178462326, compound

Product 1

HCID 178462327HCID 178462327, compound

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

adding anhydrous hydrogen chloride in an polar solvent such as isopropanol to a solution of 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-phenyl)ethoxy)-4-(5-(dimethylamino)methyl-1,2,3-triazol-4-yl)methyl-3-(S)-(4-fluorophenyl)-morpholine in second polar solvent such as ethyl acetate, followed by addition of an antisolvent such as heptane to give Form I of 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)4-(5-(dimethylamino)methyl-1,2,3-triazol-4-yl)methyl-3-(S)-(4-fluorophenyl)morpholine hydrochloride.

Sources & evidence

ORD record
ord-a4e94923fb394e658b89d518af95bd3d
Source dataset
uspto-grants-2002_08
Patent number
US06432952B1

Reaction notes

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