HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2303316Generated: November 1, 2026
Trifluoroacetic acid → 5-((dimethylamino)methyl)-2H-1,2,3-triazole-4-carbaldehyde
https://huagongshe.com/reaction/2303316
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | HCID 178519887 | HCID 178519887 | — |
| Solvent | Propan-2-ol--water (1/1) | HCID 21889133 | — |
| Product | 5-((dimethylamino)methyl)-2H-1,2,3-triazole-4-carbaldehyde | HCID 9881830 | — |
Reaction Steps
The piperidine adduct (62.1 g, 87 wt %, 54.0 g assay, 0.117 mol) was slurried in IPA/water (98:2, 365 mL). TFA (26.7 g, 18.0 mL, 0.234 mol) was added over 10 minutes maintaining the temperature at 20-25° C. The triazole aldehyde was liberated during the pH adjustment. The product crystallized from the reaction mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06432952B1 |
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| Source dataset | uspto-grants-2002_08 |
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| ORD ID | ord-8d1129c3b0204a568f76912a0042587f |
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| Source note | uspto-grants-2002_08 |
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