反应详情

温度

22.5 °C

The piperidine adduct (62.1 g, 87 wt %, 54.0 g assay, 0.117 mol) was slurried in IPA/water (98:2, 365 mL). TFA (26.7 g, 18.0 mL, 0.234 mol) was added over 10 minutes maintaining the temperature at 20-25° C. The triazole aldehyde was liberated during the pH adjustment. The product crystallized from the reaction mixture.

1. customThe product crystallized from the reaction mixture