HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 22958912, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | Trimethylsilyl iodide | HCID 85247 | — |
| Reactant | 3-(2-Fluoro-benzylcarbamoyl)-8-aza-bicyclo[3.2.1]octane-8-carboxylic Acid Ethyl Ester | HCID 22958905 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 22958912 | HCID 22958912 | 76.5% |
Reaction Steps
A solution of 0.15 g of 3-(2-fluoro-benzylcarbamoyl)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid ethyl ester and 0.5 mL of trimethylsilyl iodide in 25 mL of chloroform was kept at room temperature for 48 h, shaken with 25 mL of 6N NaOH and dilute sodium sulfite and dried over magnesium sulfate. Removal of solvents gave 0.09 g of a resin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432976B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-d5c637ad658f471f83bf24e669a844c4 |
| Source note | uspto-grants-2002_08 |