Sodium Hydroxide → HCID 22958912, compound

HRID 2303333Notes

Reaction equation

HRID 2303333 reaction equation
C(OC([N:6]1[CH:11]2[CH2:12][CH2:13][CH:7]1[CH2:8][CH:9]([C:14](=[O:24])[NH:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[F:23])[CH2:10]2)=O)C.C[Si](I)(C)C.[OH-].[Na+].S([O-])([O-])=O.[Na+].[Na+]>C(Cl)(Cl)Cl>[F:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH2:16][NH:15][C:14]([CH:9]1[CH2:10][CH:11]2[NH:6][CH:7]([CH2:13][CH2:12]2)[CH2:8]1)=[O:24]

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 24437Sodium SulfiteHCID 85247Trimethylsilyl iodideHCID 22958905HCID 22958905, compound

Product 1

HCID 22958912HCID 22958912, compoundYield 76.5%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 0.15 g of 3-(2-fluoro-benzylcarbamoyl)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid ethyl ester and 0.5 mL of trimethylsilyl iodide in 25 mL of chloroform was kept at room temperature for 48 h, shaken with 25 mL of 6N NaOH and dilute sodium sulfite and dried over magnesium sulfate. Removal of solvents gave 0.09 g of a resin.

Workup

  1. dry with materialdried over magnesium sulfate
  2. customRemoval of solvents

Sources & evidence

ORD record
ord-d5c637ad658f471f83bf24e669a844c4
Source dataset
uspto-grants-2002_08
Patent number
US06432976B1

Reaction notes

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