Acetic Acid → HCID 18626419, compound

HRID 2303342Notes

Reaction equation

HRID 2303342 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([CH:19]3[CH2:24][CH2:23][N:22](C(OCC4C=CC=CC=4)=O)[CH2:21][CH2:20]3)=[CH:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[C:35]([OH:38])(=[O:37])[CH3:36]>[Pd]>[C:35]([OH:38])(=[O:37])[CH3:36].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)=[CH:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 18626421HCID 18626421, compound

Product 1

HCID 18626419HCID 18626419, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The product of Step 3 (183 mg) was dissolved in 5 ml of acetic acid. The solution was hydrogenated over 25 hours at atmospheric pressure in the presence of 10 mg of 10% Pd/C. The mixture was filtered and the filtrate was concentrated in vacuo to give the product. FAB ms: C20H20N3F:321; Observed: 322 (M++1).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo
  3. customto give the product

Sources & evidence

ORD record
ord-8a09144e83d94fb4871cd38191db537b
Source dataset
uspto-grants-2002_08
Patent number
US06432980B1

Reaction notes

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