4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine → Hydrochloric Acid

HRID 2303363Notes

Reaction equation

HRID 2303363 reaction equation
[CH3:1][C@@H:2]1[NH:7][CH2:6][CH2:5][N:4]([CH2:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([C:15]3[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3)[CH:10]=2)[C:3]1=[O:27].[Cl:28][CH2:29][C:30]1[CH:35]=[CH:34][N:33]=[C:32]([C:36]2[CH:41]=[C:40]([O:42][CH3:43])[C:39]([O:44][CH3:45])=[C:38]([O:46][CH3:47])[CH:37]=2)[CH:31]=1>>[CH3:1][C@@H:2]1[N:7]([CH2:29][C:30]2[CH:35]=[CH:34][N:33]=[C:32]([C:36]3[CH:41]=[C:40]([O:42][CH3:43])[C:39]([O:44][CH3:45])=[C:38]([O:46][CH3:47])[CH:37]=3)[CH:31]=2)[CH2:6][CH2:5][N:4]([CH2:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([C:15]3[CH:16]=[C:17]([O:25][CH3:26])[C:18]([O:23][CH3:24])=[C:19]([O:21][CH3:22])[CH:20]=3)[CH:10]=2)[C:3]1=[O:27].[ClH:28]

Participants

4

Reactant 2

HCID 120192374-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridineHCID 12019239HCID 12019239, compound

Product 2

HCID 313Hydrochloric AcidHCID 10304665HCID 10304665, compound

Procedure

(3S)-3-Methyl-2-oxo-1-[[2-(3,4,5-trimethoxy-phenyl)pyridin-4-yl]methyl]piperazine (80 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (63 mg) were reacted in the same manner as in Example 4 to obtain the title compound as a hydrochloride.

Sources & evidence

ORD record
ord-bea82f1df5a1426782f7b3abe990f8fb
Source dataset
uspto-grants-2002_08
Patent number
US06432957B1

Reaction notes

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