4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine → Hydrochloric Acid

HRID 2303368Notes

Reaction equation

HRID 2303368 reaction equation
[CH3:1][CH:2]([CH3:30])[CH2:3][C@@H:4]1[NH:9][CH2:8][CH2:7][N:6]([CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([C:17]3[CH:22]=[C:21]([O:23][CH3:24])[C:20]([O:25][CH3:26])=[C:19]([O:27][CH3:28])[CH:18]=3)[CH:12]=2)[C:5]1=[O:29].[Cl:31][CH2:32][C:33]1[CH:38]=[CH:37][N:36]=[C:35]([C:39]2[CH:44]=[C:43]([O:45][CH3:46])[C:42]([O:47][CH3:48])=[C:41]([O:49][CH3:50])[CH:40]=2)[CH:34]=1>>[CH3:1][CH:2]([CH3:30])[CH2:3][C@@H:4]1[N:9]([CH2:32][C:33]2[CH:38]=[CH:37][N:36]=[C:35]([C:39]3[CH:44]=[C:43]([O:45][CH3:46])[C:42]([O:47][CH3:48])=[C:41]([O:49][CH3:50])[CH:40]=3)[CH:34]=2)[CH2:8][CH2:7][N:6]([CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([C:17]3[CH:22]=[C:21]([O:23][CH3:24])[C:20]([O:25][CH3:26])=[C:19]([O:27][CH3:28])[CH:18]=3)[CH:12]=2)[C:5]1=[O:29].[ClH:31]

Participants

4

Reactant 2

HCID 120192374-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridineHCID 12019242HCID 12019242, compound

Product 2

HCID 313Hydrochloric AcidHCID 10211896HCID 10211896, compound

Procedure

(3S)-3-(2-methylpropyl)-2-oxo-1-[[2-(3,4,5-trimethoxy-phenyl)pyridin-4-yl]methyl]piperazine (100 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (71 mg) were reacted in the same manner as in Example 4 to obtain the title compound as a hydrochloride.

Sources & evidence

ORD record
ord-2e4a4a68e2b04cf2a2d04769a7329614
Source dataset
uspto-grants-2002_08
Patent number
US06432957B1

Reaction notes

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