Cesium carbonate → HCID 18461151, compound

HRID 2303380Notes

Reaction equation

HRID 2303380 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=[CH:17][C:11]=3[C:10]=2[C:20]([C:22]2[CH:27]=[CH:26][C:25]([OH:28])=[C:24]([C:29]#[N:30])[CH:23]=2)=[O:21])=[CH:5][CH:4]=1.[Cl:31][CH2:32][CH2:33][N:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1.C([O-])([O-])=O.[Cs+].[Cs+]>>[ClH:31].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=[CH:17][C:11]=3[C:10]=2[C:20]([C:22]2[CH:27]=[CH:26][C:25]([O:28][CH2:32][CH2:33][N:34]3[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]3)=[C:24]([C:29]#[N:30])[CH:23]=2)=[O:21])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 748271-(2-Chloroethyl)piperidineHCID 18461165HCID 18461165, compound

Product 1

HCID 18461151HCID 18461151, compoundYield 81.4%

Procedure

1.6 g of the title compound was prepared from 1.45 g (3.49 mmol) of [2-(4-methoxyphenyl)-6-methoxybenzo[b]thien-3-yl][3-cyano-4-hydroxyphenyl]methanone, 1.3 g(7 mmol) of 1-(2-chloroethyl)piperidine, and 4.9 g (15 mmol) of Cs2CO3 in a manner similar to that in Preparation 2.

Workup

  1. customin Preparation 2

Sources & evidence

ORD record
ord-b4bfbcea142c49b8a7d5f53e7a4864db
Source dataset
uspto-grants-2002_08
Patent number
US06432982B1

Reaction notes

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