4-Nitrobenzyl chloride → HCID 15521669, compound

HRID 2303390Notes

Reaction equation

HRID 2303390 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8](=[O:20])[C:9]([C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[NH:13][CH:12]=2)=[O:10])=[CH:3][CH:2]=1.[N+:21]([C:24]1[CH:31]=[CH:30][C:27]([CH2:28]Cl)=[CH:26][CH:25]=1)([O-:23])=[O:22]>>[N:1]1[CH:2]=[CH:3][C:4]([NH:7][C:8](=[O:20])[C:9]([C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]([CH2:28][C:27]3[CH:30]=[CH:31][C:24]([N+:21]([O-:23])=[O:22])=[CH:25][CH:26]=3)[CH:12]=2)=[O:10])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 74824-Nitrobenzyl chlorideHCID 22349913HCID 22349913, compound

Product 1

HCID 15521669HCID 15521669, compoundYield 64%

Procedure

The N-(pyridin-4-yl)-(indol-3-yl)glyoxylamide obtained according to the 1st Stage (Scheme 2) is reacted with 4-nitrobenzyl chloride according to the “benzylation procedure” (page 5) and the compound N-(pyridin-4-yl)-[1-(4-nitrobenzyl)indol-3-yl]glyoxylamide obtained is isolated.

Sources & evidence

ORD record
ord-e92d58886bc8467f81d51b5f90e1f7bb
Source dataset
uspto-grants-2002_08
Patent number
US06432987B1

Reaction notes

Loading…