Glycol monoethyl ether → HCID 18461245, compound

Temperature

80 °C

2,3,5-Trichloropyridine (9.12 g, 0.050 mol) and 2-ethoxyethanol (5.40 g, 0.060 mol) were dissolved in 50 mL DMSO, followed by portionwise addition of NaH (2.4 g, 60% dispersion in oil, 0.060 mol). The mixture was heated to 80° C. for 3 hours, stirred at room temperature overnight, then heated to 120° C. for 5 hours. The reaction mixture was then diluted to 900 mL with brine, and extracted three times with 100 mL ether. The ether extracts were combined, washed twice with 100 mL water, diluted with 300 mL hexane, filtered through phase-separating paper, and concentrated in vacuo. The residue was purified via silica gel chromatography (first column with 10-50% EtOAc in hexane; second column with 0-10% EtOAc in hexane). Concentration of pure fractions gave 3,6-dichloro-2-(2-ethoxyethyl)pyridine as the major isomer (5.78 g white solid, M.P. 33-34° C.) and 2,3-dichloro-6-(2-ethoxyethyl)pyridine as the minor isomer (1.43 g white solid, M.P. 47-48° C.).

1. temperatureheated to 120° C. for 5 hours
2. extractionextracted three times with 100 mL ether
3. washwashed twice with 100 mL water
4. additiondiluted with 300 mL hexane
5. filtrationfiltered
6. customthrough phase-separating paper
7. concentrationconcentrated in vacuo
8. customThe residue was purified via silica gel chromatography (first column with 10-50% EtOAc in hexane; second column with 0-10% EtOAc in hexane)

ORD record

ord-b06e1fde164d47c0b0d1d620490b4ba5

Source dataset

uspto-grants-2002_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06432990B1