Potassium tert-butoxide → HCID 18461555, compound

HRID 2303470Notes

Reaction equation

HRID 2303470 reaction equation
C([O:3][C:4](=O)[C:5]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:6]=1[O:15][CH2:16][C:17]#[N:18])C.CC(C)([O-])C.[K+]>C1(C)C=CC=CC=1>[OH:3][C:4]1[C:5]2[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:6]=2[O:15][C:16]=1[C:17]#[N:18]

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 69910038HCID 69910038, compound

Product 1

HCID 18461555HCID 18461555, compoundYield 149.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
110 °C

Procedure

A suspension of 12 (4.0 g) in toluene was treated with potassium tert-butoxide (30 mL, 1 M in tert-butanol) under an inert atmosphere. After heating at 110° C. for 1 h, the mixture was cooled and the resulting precipitate was collected by filtration. The precipitate was washed with Et2O (3 times) giving 5 g of 3-hydroxy-6-methanesulfonyl-benzofuran-2-carbonitrile 13 as a yellow solid.

Workup

  1. temperaturethe mixture was cooled
  2. filtrationthe resulting precipitate was collected by filtration
  3. washThe precipitate was washed with Et2O (3 times)

Sources & evidence

ORD record
ord-4e0d77dc175e4e6fae4fba1854ff0d0d
Source dataset
uspto-grants-2002_08
Patent number
US06433005B1

Reaction notes

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