Iodoethane → HCID 86587907, compound

HRID 2303552Notes

Reaction equation

HRID 2303552 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][C:3]=1[C:4]#N.[CH2:11](I)[CH3:12].[CH:14]1([NH:20][OH:21])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[F:1][C:2]1[CH:9]=[C:8]([O:10][CH2:11][CH3:12])[CH:7]=[CH:6][C:3]=1[CH:4]=[N+:20]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[O-:21]

Participants

4

Reactant 3

HCID 6340IodoethaneHCID 72935CyclohexylhydroxylamineHCID 27346752-Fluoro-4-hydroxybenzonitrile

Product 1

HCID 86587907HCID 86587907, compound

Procedure

The title compound was prepared according to the procedure described in Example 29 using 2-fluoro-4-hydroxybenzonitrile, ethyl iodide and N-cyclohexylhydroxylamine. The title compound was isolated in 58.8% overall yield as slightly yellowish crystals, m.p. 112.7° C. (Rf=0.17 on a silica gel plate using hexanes/ethyl acetate, 4:1, v:v, as the eluant).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-46efbf401b12417b89feaa6e8541844e
Source dataset
uspto-grants-2002_08
Patent number
US06433008B1

Reaction notes

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