Acetyl chloride → HCID 70003051, compound

HRID 2303582Notes

Reaction equation

HRID 2303582 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[F:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH2:10][CH2:9]2.C(N(CC)CC)C>C(Cl)Cl.O>[F:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]([C:1](=[O:3])[CH3:2])[CH2:9]2

Participants

6

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 27744635-Fluoroindoline

Product 1

HCID 70003051HCID 70003051, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

Acetyl chloride (3 ml) was added dropwise to a solution of 7 grams of crude 5-fluoro-2,3-dihydro-1H-indole and 3 ml of triethylamine in 100 ml of CH2Cl2 at 0° C. After two hours, the reaction was diluted with water. The methylene chloride layer was seperated, dried and evaporated to afford 7.3 grams of crude product which was purified on silica gel eluting with hexane/ethyl acetate to give 3.3 grams of the titled compound.

Workup

  1. customThe methylene chloride layer was seperated
  2. customdried
  3. customevaporated
  4. customto afford 7.3 grams of crude product which
  5. customwas purified on silica gel eluting with hexane/ethyl acetate

Sources & evidence

ORD record
ord-eed1fef0e41549b9aa58e02d427de1d1
Source dataset
uspto-grants-2002_08
Patent number
US06433009B1

Reaction notes

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