Hydrochloric Acid → HCID 131723149, compound

HRID 2303673Notes

Reaction equation

HRID 2303673 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([CH2:21][CH3:22])[C:15]=2[CH3:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:23])[C:16]([CH2:21][CH3:22])=[N:17]1)[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21912727HCID 21912727, compound

Product 1

HCID 131723149HCID 131723149, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1-(t-butoxycarbonyl)-4-(1,3-diethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (348 mg) (from Step E) in 2.5 N HCl in methanol was stirred at rt for 16 h. The solution was concentrated and the resulting solid was suspended in ethyl acetate, filtered and dried to afford 293 mg (92%) of the title compound.

Workup

  1. concentrationThe solution was concentrated
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-6dc801861839450b8dcecd750c27abee
Source dataset
uspto-grants-2002_08
Patent number
US06432981B1

Reaction notes

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