HCID 10165687, compound → HCID 88008002, compound

HRID 2303760Notes

Reaction equation

HRID 2303760 reaction equation
[Cl:1][C:2]1[C:34]([CH3:35])=[C:33]([OH:36])[C:32]([CH3:37])=[CH:31][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]2[N:12]=[C:11]([CH2:13][O:14][C:15]3[CH:28]=[CH:27][C:18]([CH2:19][CH:20]4[S:24][C:23](=[O:25])[NH:22][C:21]4=[O:26])=[CH:17][CH:16]=3)[N:10]([CH3:29])[C:9]=2[CH:30]=1.Cl.C(OCC)(=O)C>>[ClH:1].[Cl:1][C:2]1[C:34]([CH3:35])=[C:33]([OH:36])[C:32]([CH3:37])=[CH:31][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]2[N:12]=[C:11]([CH2:13][O:14][C:15]3[CH:28]=[CH:27][C:18]([CH2:19][CH:20]4[S:24][C:23](=[O:25])[NH:22][C:21]4=[O:26])=[CH:17][CH:16]=3)[N:10]([CH3:29])[C:9]=2[CH:30]=1

Participants

3

Reactant 2

HCID 10165687HCID 10165687, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 88008002HCID 88008002, compoundYield 196.9%

Procedure

Using 2.54 g of 5-{4-[6-(2-chloro-4-hydroxy-3,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl}thiazolidine-2,4-dione and 50 ml of a 4N hydrochloric acid/ethyl acetate solution, reaction and purification were carried out in a similar manner to that described in Example (2-2b), whereby 2.67 g of the title compound were obtained.

Sources & evidence

ORD record
ord-f0e53350d6ff49a2aeff9003fe20265b
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

Loading…