Hydrochloric Acid → HCID 88008205, compound

HRID 2303766Notes

Reaction equation

HRID 2303766 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([O:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:24][O:25][C:26]1[CH:39]=[CH:38][C:29]([CH2:30][CH:31]2[S:35][C:34](=[O:36])[NH:33][C:32]2=[O:37])=[CH:28][CH:27]=1.[ClH:40]>O1CCOCC1>[ClH:40].[ClH:40].[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([O:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:24][O:25][C:26]1[CH:39]=[CH:38][C:29]([CH2:30][CH:31]2[S:35][C:34](=[O:36])[NH:33][C:32]2=[O:37])=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 77844988HCID 77844988, compound

Product 1

HCID 88008205HCID 88008205, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

0.64 g of 5-{4-(1-methyl-6-[2-(morpholin-4-yl)phenoxy]-1H-benzimidazol-2-ylmethoxy)benzyl}thiazolidine-2,4-dione were dissolved in a mixture of 30 ml of concentrated hydrochloric acid and 30 ml of 1,4-dioxane. The resulting solution was stirred at room temperature for 90 minutes. The reaction mixture was evaporated to dryness, followed by the addition of ether. The insoluble product was collected by filtration and washed with ether, whereby 0.71 g of the title compound were obtained.

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. additionfollowed by the addition of ether
  3. filtrationThe insoluble product was collected by filtration
  4. washwashed with ether

Sources & evidence

ORD record
ord-f4654361877b4d0ab95f83c05620dbac
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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