HCID 18461431, compound → HCID 86758427, compound

HRID 2303768Notes

Reaction equation

HRID 2303768 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:47]=[CH:46][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([N:31]5[CH2:36][CH2:35][O:34][CH2:33][CH2:32]5)[CH:26]=4)=[CH:20][C:19]=3[N:37](C)[C:38](=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:48].O1CCOCC1>>[ClH:48].[ClH:48].[CH3:38][N:37]1[C:19]2[CH:20]=[C:21]([O:24][C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)[CH:26]=3)[CH:22]=[CH:23][C:18]=2[N:17]=[C:15]1[CH2:14][O:13][C:12]1[CH:46]=[CH:47][C:9]([CH2:8][CH:4]2[S:3][C:2](=[O:1])[NH:6][C:5]2=[O:7])=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 18461431HCID 18461431, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 86758427HCID 86758427, compound

Procedure

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-[3-(morpholin-4-yl)phenoxy]phenyl)-N-methylcarbamate and 20 ml of 4N hydrochloric acid/dioxane was stirred at room temperature for 3 hours. The reaction mixture was evaporated to dryness under reduced pressure, followed by the addition of ether. The insoluble product was collected by filtration and washed with ether, whereby 1.27 g of the title compound were obtained.

Workup

  1. customThe reaction mixture was evaporated to dryness under reduced pressure
  2. additionfollowed by the addition of ether
  3. filtrationThe insoluble product was collected by filtration
  4. washwashed with ether

Sources & evidence

ORD record
ord-34650a43780042b390e542ad0fb04735
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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