HCID 18461336, compound → HCID 77844928, compound

HRID 2303775Notes

Reaction equation

HRID 2303775 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:46]=[CH:45][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[N:31]4[CH2:35][CH2:34][CH2:33][CH2:32]4)=[CH:20][C:19]=3[N:36](C)[C:37](=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.Cl.O1CCOCC1>>[CH3:37][N:36]1[C:19]2[CH:20]=[C:21]([O:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[N:31]3[CH2:32][CH2:33][CH2:34][CH2:35]3)[CH:22]=[CH:23][C:18]=2[N:17]=[C:15]1[CH2:14][O:13][C:12]1[CH:11]=[CH:10][C:9]([CH2:8][CH:4]2[S:3][C:2](=[O:1])[NH:6][C:5]2=[O:7])=[CH:46][CH:45]=1

Participants

3

Reactant 2

HCID 18461336HCID 18461336, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 77844928HCID 77844928, compoundYield 92%

Procedure

In a similar manner to that described in Example (2-2a), a reaction was carried out using t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-[2-(pyrrolidin-1-yl)phenoxy]phenyl}-N-methylcarbamate (1.25 g) and 4N hydrogen chloride/dioxane (25 ml) and the reaction mixture was purified to give the title compound (0.94 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-8bf61149e27340d3aad3eca0bf7482c6
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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