HCID 18461375, compound → HCID 86758435, compound

HRID 2303786Notes

Reaction equation

HRID 2303786 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:44]=[CH:43][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([CH3:32])[C:26]=4[CH3:33])=[CH:20][C:19]=3[N:34]([CH3:42])C(=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:45].O1CCOCC1>>[ClH:45].[OH:31][C:28]1[CH:29]=[CH:30][C:25]([O:24][C:21]2[CH:22]=[CH:23][C:18]3[N:17]=[C:15]([CH2:14][O:13][C:12]4[CH:43]=[CH:44][C:9]([CH2:8][CH:4]5[S:3][C:2](=[O:1])[NH:6][C:5]5=[O:7])=[CH:10][CH:11]=4)[N:34]([CH3:42])[C:19]=3[CH:20]=2)=[C:26]([CH3:33])[C:27]=1[CH3:32]

Participants

3

Reactant 2

HCID 18461375HCID 18461375, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 86758435HCID 86758435, compound

Procedure

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(4-hydroxy-2,3-dimethylphenoxy)phenyl}-N-methylcarbamate (2.35 g) and 4N hydrogen chloride/dioxane (20 ml) was stirred at ambient temperature for 44 hours. The solvent of the reaction mixture was evaporated to dryness. To the residue was added ethyl acetate and insoluble product was collected by filtration and washed with ethyl acetate to give the title compound (1.82 g).

Workup

  1. customThe solvent of the reaction mixture was evaporated to dryness
  2. additionTo the residue was added ethyl acetate and insoluble product
  3. filtrationwas collected by filtration
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-bf23e55735734ef6834d0aa9dbcb54be
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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