HCID 85830812, compound → HCID 66912321, compound

HRID 230380Notes

Reaction equation

HRID 230380 reaction equation
C(C[N:10]1[CH:14]=[C:13](C2C=CC=CC=2)[N:12]=[CH:11]1)(=O)C1C=CC=CC=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH:12]1[C:13]2[N:10]=[CH:14][CH:13]=[N:12][C:14]=2[NH:10][CH2:11]1

Participants

4

Reactant 1

HCID 85830812HCID 85830812, compound

Product 1

HCID 66912321HCID 66912321, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
20 °C

Procedure

A solution of 2-[1(S)-{1,1-dimethylethoxy)carbonylamino}-2-(3-indolyl)ethyl]-1-(benzoylmethyl)-4-phenyl-1H-imidazole (prepared as described previously) (100 mg) in a mixture of 10% TFA in DCM (1.3 mL) was stirred for about 3 hours at about 20° C. and concentrated under reduced pressure to yield the expected dihydro-imidazo-pyrazine (yield=95%). LC/MS: calculated MW: 402.19, m/z=403.2 (M+H).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-44a8eeab64464a3689443ca6134e3c8b
Source dataset
uspto-grants-2009_07
Patent number
US07566734B2

Reaction notes

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