1,4-Dioxane hydrochloride → HCID 178478924, compound

HRID 2303819Notes

Reaction equation

HRID 2303819 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:46]=[CH:45][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][C:28]([C:31]5[NH:35][N:34]=[N:33][N:32]=5)=[CH:27][CH:26]=4)=[CH:20][C:19]=3[N:36](C)[C:37](=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:47].O1CCOCC1>>[ClH:47].[NH:32]1[C:31]([C:28]2[CH:27]=[CH:26][C:25]([O:24][C:21]3[CH:22]=[CH:23][C:18]4[N:17]=[C:15]([CH2:14][O:13][C:12]5[CH:11]=[CH:10][C:9]([CH2:8][CH:4]6[S:3][C:2](=[O:1])[NH:6][C:5]6=[O:7])=[CH:46][CH:45]=5)[N:36]([CH3:37])[C:19]=4[CH:20]=3)=[CH:30][CH:29]=2)=[N:35][N:34]=[N:33]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178486014HCID 178486014, compound

Product 1

HCID 178478924HCID 178478924, compound

Procedure

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidine-5-ylmethyl)phenoxyacetylamino]-5-[4-(tetrazol-5-yl)phenoxy]phenyl}-N-methylcarbamate (0.76 g) and 4N hydrogen chloride/dioxane (20 ml) was stirred at ambient temperature for 24 hours. The solvent of the reaction mixture was evaporated. To the residue was added ethyl acetate and insoluble product was isolated by filtration and washed with ethyl acetate to give the title compound (0.44 g).

Workup

  1. customThe solvent of the reaction mixture was evaporated
  2. additionTo the residue was added ethyl acetate
  3. custominsoluble product was isolated by filtration
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-812b4ce266ad4034acb59624661bb988
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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