反应详情

A mixture of 57.0 g of t-butyl N-[5-(4-methoxymethoxy-2,3,5-trimethylphenoxy)-2-nitrophenyl]-N-methylcarbamate, 3 g of 10% palladium on carbon and 500 ml of methanol was vigorously stirred at room temperature for 8 hours under a hydrogen atmosphere. The palladium on carbon in the reaction mixture was filtered off and the filtrate was concentrated by evaporation. The residue was purified by chromatography through a silica gel column (eluting solvent: n-hexane/ethyl acetate=3/1), whereby 52.5 g of the title compound were obtained.

1. filtrationThe palladium on carbon in the reaction mixture was filtered off
2. concentrationthe filtrate was concentrated by evaporation
3. customThe residue was purified by chromatography through a silica gel column (eluting solvent: n-hexane/ethyl acetate=3/1)