HCID 18461411, compound → t-Butyl N-[2-amino-5-(4-methoxymethoxy-2,3,5-trimethylphenoxy)phenyl]N-methylcarbamate

Participants

Reaction Steps

A mixture of 57.0 g of t-butyl N-[5-(4-methoxymethoxy-2,3,5-trimethylphenoxy)-2-nitrophenyl]-N-methylcarbamate, 3 g of 10% palladium on carbon and 500 ml of methanol was vigorously stirred at room temperature for 8 hours under a hydrogen atmosphere. The palladium on carbon in the reaction mixture was filtered off and the filtrate was concentrated by evaporation. The residue was purified by chromatography through a silica gel column (eluting solvent: n-hexane/ethyl acetate=3/1), whereby 52.5 g of the title compound were obtained.

Provenance & Evidence