Chloromethyl Methyl Ether → HCID 18461391, compound

Participants

Reaction Steps

To 50 ml of an anhydrous tetrahydrofuran suspension containing 1.72 g of sodium hydride (55% by weight), 6.75 g of 2,6-dimethyl-4-pivaloyloxyphenol were added in small portions, followed by stirring at room temperature for 30 minutes. To the reaction mixture, 3.18 g of chloromethyl methyl ether were added and the resulting mixture was stirred at the same temperature for 3 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The extract was dried over anhydrous sodium sulfate and the solvent was distilled off under reduced pressure, whereby 8.17 g of 4-methoxymethoxy-3,5-dimethylphenyl pivaloate were obtained as a crude product.

Provenance & Evidence