反应详情

To 50 ml of an anhydrous tetrahydrofuran suspension containing 1.72 g of sodium hydride (55% by weight), 6.75 g of 2,6-dimethyl-4-pivaloyloxyphenol were added in small portions, followed by stirring at room temperature for 30 minutes. To the reaction mixture, 3.18 g of chloromethyl methyl ether were added and the resulting mixture was stirred at the same temperature for 3 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The extract was dried over anhydrous sodium sulfate and the solvent was distilled off under reduced pressure, whereby 8.17 g of 4-methoxymethoxy-3,5-dimethylphenyl pivaloate were obtained as a crude product.

1. additionwere added in small portions
2. stirringthe resulting mixture was stirred at the same temperature for 3 hours
3. extractionfollowed by extraction with ethyl acetate
4. dry with materialThe extract was dried over anhydrous sodium sulfate
5. distillationthe solvent was distilled off under reduced pressure