HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-(N-t-Butoxycarbonyl-N-methylamino)-4-(4-amino-3,5-dimethylphenoxy)nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Amino-3,5-dimethylphenol | HCID 76543 | — |
| Reactant | tert-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate | HCID 15544598 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(N-t-Butoxycarbonyl-N-methylamino)-4-(4-amino-3,5-dimethylphenoxy)nitrobenzene | HCID 18184997 | 73.4% |
Reaction Steps
By using 1.10 g of 4-amino-3,5-dimethylphenol, 2.29 g of t-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate, 0.35 g of sodium hydride (55% by weight) and 30 ml of anhydrous N,N-dimethylformamide, reaction and purification were carried out in a similar manner to that described in Reference Example 6, whereby 2.27 g of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432993B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-1f5def646059497786910081e9c84592 |
| Source note | uspto-grants-2002_08 |