HCID 18461417, compound → HCID 18461288, compound

HRID 2303855Notes

Reaction equation

HRID 2303855 reaction equation
[CH3:1][O:2][CH2:3][O:4][C:5]1[C:29]([CH3:30])=[CH:28][C:8]([O:9][C:10]2[CH:11]=[CH:12][C:13]([N+:25]([O-])=O)=[C:14]([N:16]([CH3:24])[C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH:15]=2)=[CH:7][C:6]=1[CH3:31]>[Pd].CO>[NH2:25][C:13]1[CH:12]=[CH:11][C:10]([O:9][C:8]2[CH:7]=[C:6]([CH3:31])[C:5]([O:4][CH2:3][O:2][CH3:1])=[C:29]([CH3:30])[CH:28]=2)=[CH:15][C:14]=1[N:16]([CH3:24])[C:17](=[O:23])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22]

Participants

4

Reactant 1

HCID 18461417HCID 18461417, compound

Product 1

HCID 18461288HCID 18461288, compoundYield 93.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

By using 3.12 g of t-butyl N-[5-(4-methoxymethoxy-3,5-dimethylphenoxy)-2-nitrophenyl]-N-methylcarbamate, 0.33 g of 10% palladium on carbon and 30 ml of methanol, reaction and purification were carried out in a similar manner to that described in Reference Example 7, whereby 2.72 g of the title compound were obtained.

Sources & evidence

ORD record
ord-03bb081ff89e41d4bf68d88105d108d1
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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