Methanol → HCID 18461440, compound

HRID 2303859Notes

Reaction equation

HRID 2303859 reaction equation
[N:1]1([C:7]2[CH:8]=[C:9]([CH:29]=[CH:30][CH:31]=2)[O:10][C:11]2[CH:12]=[CH:13][C:14]([N+:26]([O-])=O)=[C:15]([N:17]([CH3:25])[C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH:16]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.CO>[Pd].C1(C)C=CC=CC=1>[NH2:26][C:14]1[CH:13]=[CH:12][C:11]([O:10][C:9]2[CH:29]=[CH:30][CH:31]=[C:7]([N:1]3[CH2:2][CH2:3][O:4][CH2:5][CH2:6]3)[CH:8]=2)=[CH:16][C:15]=1[N:17]([CH3:25])[C:18](=[O:24])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23]

Participants

5

Reactant 2

HCID 887MethanolHCID 18461357HCID 18461357, compound

Product 1

HCID 18461440HCID 18461440, compoundYield 96.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 1140TolueneSolvent

Procedure

By using 5.0 g of t-butyl N-{5-[3-(morpholin-4-yl)phenoxy]-2-nitrophenyl}-N-methylcarbamate, 0.5 g of 10% palladium on carbon and a mixed solvent of 30 ml of methanol and 70 ml of toluene, reaction and purification were carried out in a similar manner to that described in Reference Example 7, whereby 4.5 g of the title compound were obtained.

Sources & evidence

ORD record
ord-0b8ba4a62bdb45c894b4acddc0a696e4
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

Loading…