HCID 18184945, compound → HCID 18184998, compound

HRID 2303882Notes

Reaction equation

HRID 2303882 reaction equation
[C:1]12([C:11]3[CH:35]=[CH:34][C:14]([O:15][C:16]4[CH:17]=[CH:18][C:19]([N+:31]([O-])=O)=[C:20]([N:22]([CH3:30])[C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH:21]=4)=[CH:13][CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>[Pd].CO>[C:1]12([C:11]3[CH:35]=[CH:34][C:14]([O:15][C:16]4[CH:17]=[CH:18][C:19]([NH2:31])=[C:20]([N:22]([CH3:30])[C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:26])[CH3:27])[CH:21]=4)=[CH:13][CH:12]=3)[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

Participants

4

Reactant 1

HCID 18184945HCID 18184945, compound

Product 1

HCID 18184998HCID 18184998, compoundYield 99.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-{5-[4-(1-adamantyl)phenoxy]-2-nitrophenyl}-N-methylcarbamate (4.28 g), palladium on carbon (10%, 0.42 g) and methanol (60 ml) and the reaction mixture was purified to give the title compound (4.00 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-80c2e5f759b64ebaa26bd9959c29e492
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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