HCID 18461377, compound → HCID 18461266, compound

HRID 2303885Notes

Reaction equation

HRID 2303885 reaction equation
[CH3:1][N:2]([C:10]1[CH:15]=[C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:13]=[CH:12][C:11]=1[N+:29]([O-])=O)[C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]>[Pd].C1(C)C=CC=CC=1.CO>[NH2:29][C:11]1[CH:12]=[CH:13][C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:15][C:10]=1[N:2]([CH3:1])[C:3](=[O:9])[O:4][C:5]([CH3:6])([CH3:7])[CH3:8]

Participants

4

Reactant 1

HCID 18461377HCID 18461377, compound

Product 1

HCID 18461266HCID 18461266, compoundYield 89.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21867641Toluene methanolSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-methyl-N-[2-nitro-5-(2-phenylphenoxy)phenyl]carbamate (8.3 g), palladium on carbon (10%, 0.66 g) and toluene/methanol=7/3 (100 ml) and the reaction mixture was purified to give the title compound (6.9 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-0e91f33b60ff474db37343d1f07d7f3b
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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