HCID 18461289, compound → HCID 18461481, compound

HRID 2303888Notes

Reaction equation

HRID 2303888 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:10]=[CH:11][C:12]([N+:24]([O-])=O)=[C:13]([N:15]([CH3:23])[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH:14]=2)=[CH:4][CH:3]=1>[Pd].CO>[NH2:24][C:12]1[CH:11]=[CH:10][C:9]([S:8][C:5]2[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=2)=[CH:14][C:13]=1[N:15]([CH3:23])[C:16](=[O:22])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21]

Participants

4

Reactant 1

HCID 18461289HCID 18461289, compound

Product 1

HCID 18461481HCID 18461481, compoundYield 90.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-[5-(4-hydroxyphenylthio)-2-nitrophenyl]-N-methylcarbamate (2.84 g), palladium on carbon (10%, 1.52 g) and methanol (50 ml) and the reaction mixture was purified to give the title compound (2.37 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-de14aebf08bd4d51bd39af56c90fca93
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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