HCID 18461263, compound → HCID 18461269, compound

HRID 2303892Notes

Reaction equation

HRID 2303892 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:13][CH:12]=2)=[CH:6][C:5]=1[N:23]([CH3:31])[C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])([O-])=O.C1(C)C=CC=CC=1.C(OCC)(=O)C>[Pd].CCCCCC.C(OCC)(=O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:15][CH:16]=2)=[CH:6][C:5]=1[N:23]([CH3:31])[C:24](=[O:30])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29]

Participants

5

Reactant 2

HCID 18461263HCID 18461263, compoundHCID 21584019Toluene ethylacetate

Product 1

HCID 18461269HCID 18461269, compoundYield 97.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21226206Ethyl acetate hexaneSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-[2-nitro-5-(4-phenylphenoxy)phenyl]-N-methylcarbamate (5.32 g), palladium on carbon (10%, 0.68 g) and toluene/ethyl acetate=1/1 (140 ml) and the reaction mixture was purified to give the title compound (4.82 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-30f84e1bb2eb447a9d6b6dc412ef8686
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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