HCID 18461307, compound → HCID 18461460, compound

HRID 2303895Notes

Reaction equation

HRID 2303895 reaction equation
[OH:1][C:2]1[C:26]([C:27]([CH3:30])([CH3:29])[CH3:28])=[CH:25][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]([N+:22]([O-])=O)=[C:11]([N:13]([CH3:21])[C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH:12]=2)=[CH:4][C:3]=1[C:31]([CH3:34])([CH3:33])[CH3:32]>[Pd].CO>[NH2:22][C:10]1[CH:9]=[CH:8][C:7]([O:6][C:5]2[CH:4]=[C:3]([C:31]([CH3:32])([CH3:33])[CH3:34])[C:2]([OH:1])=[C:26]([C:27]([CH3:29])([CH3:30])[CH3:28])[CH:25]=2)=[CH:12][C:11]=1[N:13]([CH3:21])[C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17]

Participants

4

Reactant 1

HCID 18461307HCID 18461307, compound

Product 1

HCID 18461460HCID 18461460, compoundYield 101.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-[5-(4-hydroxy-3,5-di-t-butylphenoxy)-2-nitrophenyl]-N-methylcarbamate (0.58 g), palladium on carbon (10%, 0.12 g) and methanol (20 ml) and the reaction mixture was purified to give the title compound (0.55 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-794b02fc555a4d679b038114f0c16cc9
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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