HCID 18461309, compound → HCID 18461251, compound

HRID 2303906Notes

Reaction equation

HRID 2303906 reaction equation
[CH2:1]([C:8]1[CH:32]=[CH:31][C:11]([O:12][C:13]2[CH:14]=[CH:15][C:16]([N+:28]([O-])=O)=[C:17]([N:19]([CH3:27])[C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23])[CH:18]=2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C)C=CC=CC=1.C(OCC)(=O)C>[Pd].CCCCCC.C(OCC)(=O)C>[NH2:28][C:16]1[CH:15]=[CH:14][C:13]([O:12][C:11]2[CH:10]=[CH:9][C:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:32][CH:31]=2)=[CH:18][C:17]=1[N:19]([CH3:27])[C:20](=[O:26])[O:21][C:22]([CH3:23])([CH3:25])[CH3:24]

Participants

5

Reactant 2

HCID 18461309HCID 18461309, compoundHCID 21584019Toluene ethylacetate

Product 1

HCID 18461251HCID 18461251, compoundYield 88.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21226206Ethyl acetate hexaneSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-[5-(4-benzylphenoxy)-2-nitrophenyl]-N-methylcarbamate (12.2 g), palladium on carbon (10%, 0.91 g) and toluene/ethyl acetate=1/1 (140 ml) and the reaction mixture was purified to give the title compound (10.1 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-3682f9670cbf4696a62979b594321018
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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