HCID 18461410, compound → HCID 18461361, compound

HRID 2303907Notes

Reaction equation

HRID 2303907 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][CH:26]=1)[O:5][C:6]1[CH:7]=[CH:8][C:9]([N+:21]([O-])=O)=[C:10]([N:12]([CH3:20])[C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH:11]=1.C1(C)C=CC=CC=1.C(OCC)(=O)C>[Pd].CCCCCC.C(OCC)(=O)C>[NH2:21][C:9]1[CH:8]=[CH:7][C:6]([O:5][C:4]2[CH:24]=[CH:25][CH:26]=[C:2]([OH:1])[CH:3]=2)=[CH:11][C:10]=1[N:12]([CH3:20])[C:13](=[O:19])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18]

Participants

5

Reactant 2

HCID 18461410HCID 18461410, compoundHCID 21584019Toluene ethylacetate

Product 1

HCID 18461361HCID 18461361, compoundYield 83.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21226206Ethyl acetate hexaneSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-[5-(3-hydroxyphenoxy)-2-nitrophenyl]-N-methylcarbamate (7.8 g), palladium on carbon (10%, 0.9 g) and toluene/ethyl acetate=1/1 (140 ml) and the reaction mixture was purified to give the title compound (6 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-37f815c6f49e443eb6c96e12d23bde81
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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