HCID 18461310, compound → HCID 18461278, compound

HRID 2303916Notes

Reaction equation

HRID 2303916 reaction equation
C([O:8][C:9]1[C:33]([C:34]([CH3:37])([CH3:36])[CH3:35])=[CH:32][C:12]([O:13][C:14]2[CH:15]=[CH:16][C:17]([N+:29]([O-])=O)=[C:18]([N:20]([CH3:28])[C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH:19]=2)=[C:11]([C:38]([CH3:41])([CH3:40])[CH3:39])[CH:10]=1)C1C=CC=CC=1>[Pd].C1(C)C=CC=CC=1.CO.C(OCC)(=O)C>[NH2:29][C:17]1[CH:16]=[CH:15][C:14]([O:13][C:12]2[CH:32]=[C:33]([C:34]([CH3:35])([CH3:36])[CH3:37])[C:9]([OH:8])=[CH:10][C:11]=2[C:38]([CH3:40])([CH3:41])[CH3:39])=[CH:19][C:18]=1[N:20]([CH3:28])[C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24]

Participants

4

Reactant 1

HCID 18461310HCID 18461310, compound

Product 1

HCID 18461278HCID 18461278, compoundYield 63.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 22505858HCID 22505858, compoundSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-[5-(4-benzyloxy-2,5-di-t-butylphenoxy)-2-nitrophenyl]-N-methylcarbamate (7.1 g), palladium on carbon (10%, 0.7 g) and toluene/methanol/ethyl acetate=16/16/25 (57 ml) and the reaction mixture was purified to give the title compound (3.56 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-e7a44437700d401d9ba7815bdf2d2472
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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